PECULIARITIES OF SECONDARY METABOLITES BIOSYNTHESIS IN PLANT CELL CULTURES

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A.M. NOSOV

Abstract

metabolites formation in plant cell cultures of Panax spp., (ginsenosides); Dioscorea deltoidea (steroid glycosides); Ajuga reptans, Serratula coronata, Rhaponticum carthamoides (ecdisteroids); Polyscias spp., (triterpene glycosides), Taxus spp. (taxoids), Stevia rebaudiana (diterpene steviol-glycosides), Stephania glabra (alkaloids). They are some regular trends of secondary metabolites synthesis in the plant cell culture:

It can be noted the stable synthesis of the compound promoting cell proliferation. Indeed, cell cultures of Dioscorea deltoidea were demonstrated to accumulate only furostanol glycosides, which promoted cell division. Furostanol glycoside content of Dioscorea strain DM-0.5 was up to 6 - 12% by dry biomass.

Panax ginseng and P. japonicus plant cell cultures synthesize as minimum seven triterpene glycosides (ginsenosides), the productivity of these compounds was up to 6.0 - 8.0% on dry biomass.

By contrast, the detectable synthesis of diterpene steviol-glycosides in cultivated cells of Stevia rebaudiana initiated in the mixotrophic cultures during chloroplast formation only.

Despite these differences, or mainly due to them, plant cell cultures have become an attractive source of phytochemicals in alternative to collecting wild plants. It provides a guideline to bioreactor-based production of isoprenoids using undifferentiated plant cell cultures. 

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Sending to International Journal of Secondary Metabolite