Evaluation of Antioxidant, Antimicrobial and Antimutagenic Activity with Irritation Effects of Ceramium Rubrum (Red Algae) Extract
Main Article Content
Abstract
Algae are a rare living groups that serve many different uses such as food, pharmacology, agriculture and biofuel and therefore it has been the subject of numerous studies. Although algae have a rich diversity in our country's coasts, they have not received much attention to reveal their potential activities. This study was conducted to evaluate antioxidant, antimutagenic and antimicrobial activities as well as irritation/toxicity efficacy of n-hexane, chloroform and methanol extracts of the red algae Ceramium rubrum C. Agardh. While spectrophotometric methods were used for the determination of total phenol and flavonoid content, antioxidant activity was evaluated by DPPH assay. Antimicrobial and antimutagenic efficacy of extracts were determined by MIC metod and Ames test, respectively. Also, HET-CAM test was used for irritation/toxicity of extracts. While methanol extract was found to have higher total flavonoid and phenolic contents than the other extracts and hexane showed higher antioxidant activity than other extracts. All extracts exerted moderate antimicrobial activity against tested microorganisms as 64–256 μg/mL. However, extracts of the algae did not show any mutagenicity or irritation effect even at the highest concentration. As a result, C. rubrum can potentially be used with both antioxidant activities and have no toxic effects and its antimicrobial activities can be developed against different sensible organisms.
Article Details
International Journal of Secondary Metabolite
http://ijate.net/index.php/ijsm
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).